Anti-idiotype (ID) Ab (針對抗體藥的一抗)-Antibody-盟基生物科技股份有限公司

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Primary Antibody (一級抗體)

Anti-idiotype (ID) Ab (針對抗體藥的一抗)

Anti-idiotype (ID) Ab (針對抗體藥的一抗)

Primary Antibody (一級抗體)

Anti-idiotype (ID) Ab (針對抗體藥的一抗)

用於抗體藥 Pharmacokinetic (PK) 研究 & 抗體藥免疫性 Anti-drug antibody (ADA) 研究。

點我詢問
抗獨特型 (Anti-idiotype) 抗體是一種能夠特異性結合於另一抗體之可變區的抗體，用於抗體藥 Pharmacokinetic (PK) 研究 & 抗體藥免疫性 Anti-drug antibody (ADA) 研究 (圖一、二)。除此之外，抗獨特型 (Anti-idiotype) 抗體在藥物研發領域，包括疫苗生產、藥物動力學研究與免疫篩選中扮演重要之角色。GenScript 提供多種抗獨特型 (Anti-idiotype) 抗體產品，也提供客製化服務，製作針對實驗者發展中抗體藥的抗獨特型 (Anti-idiotype) 抗體 (客製化服務請點我)。

一、產品介紹
GenScript 提供的抗獨特型 (Anti-idiotype) 抗體產品主要有兩個應用 (圖一、二)，第一個應用是以 ELISA 檢測抗體藥 Pharmacokinetic (PK，藥物動力學)，亦即抗體藥在動物或人體內的濃度變化和代謝情況 (圖一)。抗體藥於動物體內會被代謝，包含分解和排除，一個好的藥物必須能停留於體內足夠的時間，也必須能被生物體清除。市面上的抗體藥已經過嚴格品質掌控，因此，當研究者想要重複實驗、以市面上抗體藥搭配其他藥物時 (抗體藥或小分子)，必須重新測試抗體藥的藥物動力學。另外，若廠商欲發展生物性相似藥 (Biosimilars)，也必須證明和市面上抗體藥有同樣的藥物特性。
第二個應用是作為研究 Anti-drug antibody (ADA，針對抗體藥的抗體) 的陽性對照組 (圖二)。送入生物體內的抗體藥對於生物體來說屬於外源分子，因此體內免疫系統會針對抗體藥產生抗體，即為 Anti-drug antibody (ADA)。儘管抗體藥已經過人源化或其他優化，仍然有可能引起免疫反應。一旦 ADA 出現，代表此抗體藥會更容易被清除。因此也必須檢測生物體內的 ADA。Genscript 提供的這些抗獨特型 (Anti-idiotype) 抗體可算是 ADA，因此可當作實驗中的陽性對照組。
 
圖一：以 ELISA 檢測抗體藥 Pembrolizumab PK 示意圖，此應用可用來檢測樣本中 Pembrolizumab 抗體藥或生物性相似藥的含量。圖中 Capture antibody 為 Anti-Pembrolizumab Antibody, mAb, Mouse (#A01844)，detection antibody 則有 Biotin 鍵結 (#A01845)。 圖二：Anti-drug antibody (ADA) 研究示意圖，圖中 Positive control (陽性對照組) 為 Anti-Pembrolizumab Antibody, pAb, Rabbit (#A01846)。
 

二、產品優點
1.經過測試，提供 ELISA 中的抗體對 (antibody pairs) 選擇：
以 sandwich ELISA 做檢測時，需要同時有 capture 和 detection antibody，前者用於捉取目標，後者用於檢測目標。這兩個抗體必須辨認不同的抗原，才不會彼此競爭而降低靈敏度。Genscript 抗體經過抗原分析，提供適合的對照抗體 (表一)。

2. 同一種抗體藥有多種抗體選擇 (表一)
3. 提供高品質兔單株抗體，靈敏度更高：
相比於鼠單抗而言，兔單抗親和力較高，因此靈敏度更高，可到 picomolar 等級。
 
圖三： MonoRab™ Anti-Pembrolizumab Antibody (90G12F8), mAb, Rabbit (#A01853) 親和力測試，結果中顯示 Kd<10^-12M，比一般的鼠單抗更高 (Kd~10^-10M)
 

三、產品資訊
每種抗體藥提供多種對應的抗獨特型 (Anti-idiotype) 抗體，皆為40ug 包裝，凍乾粉末可穩定儲存於-20℃至少一年，回溶後可穩定儲存於-20℃至少一年或4℃兩到三週，盡量避免重複解凍。Genscript 也提供客製化服務，製作針對實驗者發展中抗體藥的抗獨特型抗體 (客製化服務請點我)。

表一：訂購資訊  
針對目標 貨號 產品名稱 IC50 (ug/mL) 應用和建議
Adalimumab/Humira (Target‎: ‎TNF alpha) A01954-40 Anti-Adalimumab Antibody (15C7), mAb, Mouse 0.258 Direct/Indirect/Inhibitory ELISA, Capture antibody for Adalimumab PK/PD bridging ELISA with A01955-40
A01955-40 Anti-Adalimumab Antibody (3C2), mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Detection antibody for Adalimumab, PK/PD bridging ELISA with A01954-40
A01956-40 Anti-Adalimumab Antibody (3C2) [Biotin], mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Detection antibody for Adalimumab, PK/PD bridging ELISA with A01954-40
A01886-40 Anti-Adalimumab Antibody, pAb, Rabbit N/A Direct ELISA, Immunogenicity assay
A01921-40 MonoRab™ Anti-Adalimumab Antibody (4E12), mAb, Rabbit 0.175 Direct/Indirect/Inhibitory ELISA, Capture antibody for Adalimumab PK/PD bridging ELISA with A01922-40
A01922-40 MonoRab™ Anti-Adalimumab Antibody (134D5), mAb, Rabbit 0.353 Direct/Indirect/Inhibitory ELISA, Detection antibody for Adalimumab, PK/PD bridging ELISA with A01921-40 
A01923-40 MonoRab™ Anti-Adalimumab Antibody (196F3), mAb, Rabbit Non-inhibitory Direct ELISA, Immunogenicity assay
Atezolizumab/Tecentriq (Target‎: ‎PD-L1) A01948-40 Anti-Atezolizumab Antibody (10G9), mAb, Mouse 0.118 Direct/Indirect/Inhibitory ELISA, Capture antibody for Atezolizumab PK/PD bridging ELISA with A01949-40
A01949-40 Anti-Atezolizumab Antibody (6B12), mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Detection antibody for Atezolizumab, PK/PD bridging ELISA with A01948-40
A01950-40 Anti-Atezolizumab Antibody (6B12) [Biotin], mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Detection antibody for Atezolizumab, PK/PD bridging ELISA with A01948-40
A01984-40 MonoRab™ Anti-Atezolizumab Antibody (55D8) mAb, Rabbit 0.391 Direct/Indirect/Inhibitory ELISA, Capture antibody for Atezolizumab PK/PD bridging ELISA with A01985-40
A01985-40 MonoRab™ Anti-Atezolizumab Antibody (43H11), mAb, Rabbit 0.847 Direct/Indirect ELISA, Detection antibody for Atezolizumab, PK/PD bridging ELISA with A01984-40
A01986-40 MonoRab™ Anti-Atezolizumab Antibody (43H11)[Biotin], mAb, Rabbit 0.847 Direct/Indirect ELISA, Detection antibody for Atezolizumab, PK/PD bridging ELISA with A01984-40
Bevacizumab/Avastin (Target: VEGF-A) A01975-40 Anti-Bevacizumab Antibody (4H1), mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Capture antibody for Bevacizumab PK/PD bridging ELISA with A01976-40
A01976-40 Anti-Bevacizumab Antibody (6C3), mAb, Mouse 0.157 Direct/Indirect/Inhibitory ELISA, Detection antibody for Bevacizumab, PK/PD bridging ELISA with A01975-40 
A01977-40 Anti-Bevacizumab Antibody (6C3)[Biotin], mAb, Mouse 0.157 Direct/Indirect/Inhibitory ELISA, Detection antibody for Bevacizumab, PK/PD bridging ELISA with A01975-40 
A01887-40 Anti-Bevacizumab Antibody, pAb, Rabbit N/A Direct ELISA, Immunogenicity assay
A01895-40 MonoRab™ Anti-Bevacizumab Antibody (30E1), mAb, Rabbit Non-inhibitory Direct/Indirect ELISA, Capture antibody for Bevacizumab, PK/PD bridging ELISA with A01896-40
A01962-40 MonoRab™ Anti-Bevacizumab Antibody (46E3), mAb, Rabbit 0.046 Direct/Indirect/Inhibitory ELISA, Detection antibody for Bevacizumab, PK/PD bridging ELISA with A01895-40
A01896-40 MonoRab™ Anti-Bevacizumab Antibody (46E3)[Biotin], mAb, Rabbit 0.046 Direct/Indirect/Inhibitory ELISA, Detection antibody for Bevacizumab, PK/PD bridging ELISA with A01895-40
Cetuximab/Erbitux (Target: EGF receptor) A01938-40 Anti-Cetuximab Antibody (18D5), mAb, Mouse 0.2073 Direct/Indirect/Inhibitory ELISA,  Detection antibody for Cetuximab, PK/PD bridging ELISA with A01939-40
A01939-40 Anti-Cetuximab Antibody (20H1), mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Capture antibody for Cetuximab, PK/PD bridging ELISA with A01938-40
A01991-40 MonoRab™ Anti-Cetuximab Antibody (69H10), mAb, Rabbit 0.039 Direct/Indirect/Inhibitory ELISA,  Capture antibody for Cetuximab, PK/PD bridging ELISA with A01992-40
A01992-40 MonoRab™ Anti-Cetuximab Antibody (90G3), mAb, Rabbit 0.015 Direct/Indirect/Inhibitory ELISA,  Detection antibody for Cetuximab, PK/PD bridging ELISA with A01991-40
A01993-40 Anti-Cetuximab Antibody, pAb, Rabbit N/A Direct ELISA, Immunogenicity assay
Daratumumab/Darzalex (Target: CD38) A01996-40 Anti-Daratumumab Antibody (11F2), mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Capture antibody for Daratumumab, PK/PD bridging ELISA with A01997-40
A01997-40 Anti-Daratumumab Antibody (6A3), mAb, Mouse 0.582 Direct/Indirect/Inhibitory ELISA, Detection antibody for Daratumumab, PK/PD bridging ELISA with A01996-40
A01998-40 Anti-Daratumumab Antibody (9A6), mAb, Mouse 0.118 Direct/Inhibitory ELISA
A02009-40 MonoRab™ Anti-Daratumumab(139B10), mAb, Rabbit 0.017 Direct/Inhibitory ELISA
Dupilumab/Dupixent (Target: IL-4Rα) A02062-40 Anti-Dupilumab Antibody, pAb, Rabbit N/A Direct ELISA, Immunogenicity assay
Durvalumab/Imfinzi (Target: CD274) A02029-40 Anti-Durvalumab Antibody (7B6), mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Capture antibody for Durvalumab, PK/PD bridging ELISA with A02030-40
A02030-40 Anti-Durvalumab Antibody (4B5), mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Detection antibody for Durvalumab, PK/PD bridging ELISA with A02029-40
A02031-40 Anti-Durvalumab Antibody (15D6), mAb, Mouse 1.37 Direct/Inhibitory ELISA
A02010-40 Anti-Durvalumab Antibody, pAb, Rabbit N/A Direct ELISA,Immunogenicity assay
Infliximab/Remicade (Target: TNF-α) A02040-40 Anti-Infliximab Antibody (27A4) , mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Capture antibody for Infliximab, PK/PD bridging ELISA with A02041-40
A02041-40 Anti-Infliximab Antibody (23H5) , mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Detection antibody for Infliximab , PK/PD bridging ELISA with A02040-40
Ipilimumab/Yervoy (Target: CTLA-4) A01859-40 Anti-Ipilimumab Antibody(26B6H7D9), mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Capture antibody for Ipilimumab, PK/PD bridging ELISA with A01858-40
A01961-40 Anti-Ipilimumab Antibody (4H6), mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Detection antibody for Ipilimumab, PK/PD bridging ELISA with A01859-40
A01858-40 Anti-Ipilimumab Antibody (4H6)[Biotin], mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Detection antibody for Ipilimumab, PK/PD bridging ELISA with A01859-40
Omalizumab/Xolair (Target: human IgE) A02060-40 Anti-Omalizumab Antibody, pAb, Rabbit N/A Direct ELISA, Immunogenicity assay
Palivizumab/Synagis (Target: RSV F) A02064-40 Anti-Palivizumab Antibody, pAb, Rabbit N/A Direct ELISA, Immunogenicity assay
Nivolumab/Opdivo (Target‎: ‎PD-1) A01847-40 Anti-Nivolumab Antibody(8G6G3D8), mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Capture antibody for Nivolumab, PK/PD bridging ELISA with A01848-40
A01965-40 Anti-Nivolumab Antibody (6G5), mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Detection antibody for Nivolumab, PK/PD bridging ELISA with A01847-40
A01848-40 Anti-Nivolumab Antibody(6G6)[Biotin], mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Detection antibody for Nivolumab, PK/PD bridging ELISA with A01847-40
A01931-40 Anti-Nivolumab Antibody, pAb, Rabbit N/A Direct ELISA, Immunogenicity assay
A01987-40 MonoRab™ Anti-Nivolumab Antibody (33H4), mAb, Rabbit 0.484 Direct/Indirect ELISA,  Capture antibody for Nivolumab, PK/PD bridging ELISA with A01988-40
A01988-40 MonoRab™ Anti-Nivolumab Antibody (40F11), mAb, Rabbit 0.171 Direct/Indirect/Inhibitory ELISA,  Detection antibody for Nivolumab, PK/PD bridging ELISA with A01987-40
A01989-40 MonoRab™ Anti-Nivolumab Antibody (40F11)[Biotin], mAb, Rabbit 0.171 Direct/Indirect/Inhibitory ELISA,  Detection antibody for Nivolumab, PK/PD bridging ELISA with A01987-40
A01990-40 MonoRab™ Anti-Nivolumab Antibody (47F6), mAb, Rabbit 0.104 Direct/Inhibitory ELISA
Ranibizumab/Lucentis (Target: VEGF-A) A02035-40 Anti-Ranibizumab Antibody (6C3), mAb, Mouse 0.85 Direct/Indirect/Inhibitory ELISA, Capture antibody for Ranibizumab, PK/PD bridging ELISA with A02036-40
A02036-40 Anti-Ranibizumab Antibody (10D12), mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Detection antibody for Ranibizumab, PK/PD bridging ELISA with A02035-40
A02037-40 Anti-Ranibizumab Antibody, pAb, Rabbit N/A Direct ELISA, Immunogenicity assay
Obinutuzumab/Gazyva (Target: CD20) A01945-40 Anti-Obinutuzumab Antibody (18H8), mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Capture antibody for Obinutuzumab PK/PD bridging ELISA with A01946-40
A01946-40 Anti-Obinutuzumab Antibody (16B7), mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Detection antibody for Obinutuzumab, PK/PD bridging ELISA with A01945-40
A01947-40 Anti-Obinutuzumab Antibody (16B7) [Biotin], mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Detection antibody for Obinutuzumab, PK/PD bridging ELISA with A01945-40
A01933-40 Anti-Obinutuzumab Antibody, pAb, Rabbit N/A Direct ELISA, Immunogenicity assay
A01966-40 MonoRab™ Anti-Obinutuzumab Antibody (8G12), mAb, Rabbit Non-inhibitory Direct/Indirect ELISA, Capture antibody for Obinutuzumab PK/PD bridging ELISA with A01967-40
A01967-40 MonoRab™ Anti-Obinutuzumab Antibody (169F10), mAb, Rabbit Non-inhibitory Direct/Indirect ELISA, Detection antibody for Obinutuzumab, PK/PD bridging ELISA with A01966-40
A01968-40 MonoRab™ Anti-Obinutuzumab Antibody (169F10) [Biotin], mAb, Rabbit Non-inhibitory Direct/Indirect ELISA, Detection antibody for Obinutuzumab, PK/PD bridging ELISA with A01966-40
Pembrolizumab/Keytruda (Target: PD-1) A01844-40 Anti-Pembrolizumab Antibody(1D6E10), mAb, Mouse Non-inhibitory Direct ELISA
A01845-40 Anti-Pembrolizumab Antibody(10E12C6)[Biotin], mAb, Mouse 0.37 Direct/Inhibitory ELISA
A01846-40 Anti-Pembrolizumab Antibody, pAb, Rabbit N/A Direct ELISA, Immunogenicity assay
A01960-40 MonoRab™ Anti-Pembrolizumab Antibody (90G12), mAb, Rabbit  0.38 Direct/Inhibitory ELISA
A01853-40 MonoRab™ Anti-Pembrolizumab Antibody(90G12)[Biotin], mAb, Rabbit 0.38 Direct/Inhibitory ELISA
A02007-40 MonoRab™ Anti-Pembrolizumab Antibody (47E5), mAb, Rabbit 0.009 Direct/Indirect/Inhibitory ELISA, Detection antibody for Pembrolizumab, PK/PD bridging ELISA with A02008
A02008-40 MonoRab™ Anti-Pembrolizumab Antibody (94B9), mAb, Rabbit 0.58 Direct/Indirect ELISA, Capture antibody for Pembrolizumab, PK/PD bridging ELISA with A02007
Rituximab/Rituxan (Target‎: ‎CD20) A01969-40 Anti-Rituximab Antibody (6C1), mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Capture antibody for Rituximab, PK/PD bridging ELISA with A01970-40
A01970-40 Anti-Rituximab Antibody (17B6), mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Detection antibody for Rituximab, PK/PD bridging ELISA with A01969-40
A01971-40 Anti-Rituximab Antibody (17B6)[Biotin], mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Detection antibody for Rituximab, PK/PD bridging ELISA with A01969-40
A01918-40 Anti-Rituximab Antibody, pAb, Rabbit N/A Direct ELISA, Immunogenicity assay
A01942-40 MonoRab™ Anti-Rituximab Antibody (137C6), mAb, Rabbit Non-inhibitory Direct/Indirect ELISA, Capture antibody for Rituximab, PK/PD bridging ELISA with A01943-40
A01943-40 MonoRab™ Anti-Rituximab Antibody (194D7), mAb, Rabbit Non-inhibitory Direct/Indirect ELISA, Detection antibody for Rituximab, PK/PD bridging ELISA with A01942-40
A01944-40 MonoRab™ Anti-Rituximab Antibody (194D7)[Biotin], mAb, Rabbit Non-inhibitory Direct/Indirect ELISA, Detection antibody for Rituximab, PK/PD bridging ELISA with A01942-40
Sarilumab/Kevzara (Target: IL-6R) A02042-40 Anti-Sarilumab Antibody (26B10) , mAb, Mouse 0.062 Direct/Indirect/Inhibitory ELISA, Capture antibody for Sarilumab , PK/PD bridging ELISA with A02043-40
A02043-40 Anti-Sarilumab Antibody (23H12) , mAb, Mouse 0.056 Direct/Indirect/Inhibitory ELISA, Detection antibody for Sarilumab, PK/PD bridging ELISA with A02042-40 
A02044-40 Anti-Sarilumab Antibody (20F5), mAb, Mouse Non-inhibitory Direct/Indirect ELISA
Tocilizumab/Actemra (Target: IL-6 receptor) A01978-40 Anti-Tocilizumab Antibody (14B10), mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Capture antibody for Tocilizumab PK/PD bridging ELISA with A01979-40
A01979-40 Anti-Tocilizumab Antibody (6C10), mAb, Mouse 0.656 Direct/Indirect/Inhibitory ELISA, Detection antibody for Tocilizumab, PK/PD bridging ELISA with A01978-40 
A01980-40 Anti-Tocilizumab Antibody (6C10)[Biotin], mAb, Mouse 0.656 Direct/Indirect/Inhibitory ELISA, Detection antibody for Tocilizumab, PK/PD bridging ELISA with A01978-40 
A01932-40 Anti-Tocilizumab Antibody, pAb, Rabbit N/A Direct ELISA, Immunogenicity assay
Trastuzumab/Herceptin (Target: HER2) A02032-40 Anti-Trastuzumab Antibody (11C4), mAb, Mouse Non-inhibitory Direct/Indirect ELISA, Capture antibody for Trastuzumab, PK/PD bridging ELISA with A02033-40
A02033-40 Anti-Trastuzumab Antibody (15H2), mAb, Mouse Non-inhibitory Direct/Indirect/Inhibitory ELISA, Detection antibody for Trastuzumab, PK/PD bridging ELISA with A02032-40 
 

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