Small molecular inhibitor-盟基生物科技股份有限公司

Inhibitor & Compound Library

Small molecular inhibitor

Small molecular inhibitor

Inhibitor & Compound Library

Small molecular inhibitor

小分子抑製劑可以與目標蛋白結合並降低其生物活性,通常用作生物學和藥理學研究的工具。


小分子抑製劑有很多優點。例如,它們易於操作,可應用於各種細胞或動物實驗; 它們具有良好的滲透性,容易穿過細胞膜; 它們具有高穩定性,可以減少實驗中的不穩定性。 小分子抑製劑因其在調節不同細胞過程(從細胞週期控制和有絲分裂到信號通路與基因表達;從遷移和傷口癒合,到細胞凋亡和自噬)方面的顯著優勢而成為近年來生命科學研究的重要工具藥物。 

 


一、產品介紹

Target Molecule Corp. (TargetMol) 是一家全球性的高科技企業,專門從事化學和生物研究產品和服務。 Targetmol 提供超過 7,000 種用於細胞信號路徑研究和藥物發現的化合物,並追踪最新的科學研究,及時提供最新最流行的抑製劑。

 

二、產品特色

1. 每月推出100-200 種新抑製劑
2. NMR 和 HPLC 驗證以確保高純度
3. 95% 以上的化合物有庫存
4. 具有競爭力的價格
5. 多種期刊引用

TargetMol使用 HPLC 和 HNMR測試質量確保所有產品的最高質量標準。 例如,圖中顯示了脂肪抑素(fatostatin)的質量控制報告,其純度經質量檢測達99.84%以上。
註:同樣的產品,與競爭對手相比,Calbiochem (EMD) 的純度達到 95%,TOCRIS 達到 97%,SIGMA 達到 98%。


除了保證最高質量標準外,TargetMol還確保最具競爭力的價格。


TargetMol的產品受到諸多研究者的青睞,被引用在各種期刊之中。詳細的引用文獻資訊可至各個產品頁面查閱。


 

三、產品類別

熱門研究標的與抑制劑
 
信號途徑(Signaling Pathways) 標的物 抑制劑
 Angiogenesis JAK Ruxolitinib,Tofacitinib Citrate,Fedratinib
EGFR Erlotinib hydrochloride, Vandetanib, Lapatinib, Gefitinib, Erlotinib, Saracatinib, Osimertinib mesylate, Lapatinib Ditosylate, Neratinib, Afatinib
HER Neratinib,Afatinib
Bcr-Abl Bosutinib,Ponatinib, Imatinib, Nilotinib, Imatinib Mesylate, Dasatinib
ALK LDK378, LDN193189, Crizotinib, SB525334, SB 431542
FGFR AZD4547, Ponatinib, Infigratinib, Nintedanib
FLT Sunitinib Malate, Crenolanib, Sorafenib, Sorafenib tosylate, Nintedanib, Quizartinib, Cabozantinib, Fedratinib
VEGFR AZD4547, Nintedanib, Vandetanib, Regorafenib, Foretinib, Cabozantinib, Sorafenib, Axitinib, Sunitinib Malate, Sorafenib tosylate, Ponatinib
BTK Ibrutinib, Saracatinib
PDGFR Nintedanib,Imatinib,Crenolanib,Imatinib Mesylate,Ponatinib,Sorafenib,tosylate,Axitinib,Sunitinib Malate,Sorafenib,
Src Saracatinib,Ponatinib,Dasatinib,Bosutinib,PRT062607 hydrochloride,Nintedanib,Ibrutinib
Syk R406, PRT062607 hydrochloride
Apoptosis Caspase Z-VAD(OMe)-FMK
c-RET Regorafenib, Cabozantinib, Fedratinib
BCL Navitoclax, Obatoclax Mesylate, ABT737, ABT199
Ferroptosis Erastin, Ferrostatin-1,Deferoxamine Mesylate
Autophagy Autophagy 3-Methyladenine, Gemcitabine, Rapamycin
Cell Cycle/Checkpoint Aurora Kinase Alisertib, 1H-Pyrazole-3-acetamide, Pyrazolanthrone, Tozasertib
ROCK Thiazovivin, Y-27632 dihydrochloride
CDK Roscovitine, Dinaciclib, Palbociclib hydrochloride, Palbociclib Isethionate
Ferroptosis Erastin, Ferrostatin-1,Deferoxamine Mesylate
PLK BI 2536, Volasertib
Wee1 Adavosertib
DNA/RNA Synthesis Temozolomide,Gemcitabine HCl,Resveratrol,Fludarabine,Gemcitabine,Cisplatin,Fluorouracil,
Chromatin/Epigenetic HDAC RGFP 966,Entinostat,Vorinostat,Mocetinostat,Panobinostat
PARP Veliparib, Olaparib, Talazoparib, Rucaparib Phosphate
Sirtuin SRT1720 hydrochloride, Resveratrol, Selisistat
DNA Methyltransferase Decitabine
Epigenetic Reader Domain BI 2536, (+)-JQ-1
JAK Ruxolitinib, Tofacitinib Citrate, Fedratinib
Aurora Kinase Alisertib, 1H-Pyrazole-3-acetamide, Pyrazolanthrone, Tozasertib
PKC Sotrastaurin
Cytoskeletal Signaling HSP Tanespimycin, Luminespib
Akt Capivasertib, MK-2206 dihydrochloride
Wnt/beta-catenin XAV939
Microtubule Associated Vincristine sulfate, Docetaxel, Paclitaxel, Colchicine
PKC Sotrastaurin
Bcr-Abl Bosutinib,Ponatinib,Imatinib,Nilotinib,Imatinib Mesylate,Dasatinib
ROCK Thiazovivin, Y-27632 dihydrochloride
DNA Damage/DNA Repair ATM/ATR KU60019, VE821, Dactolisib
DNA-PK PI103, LY294002, NU7441
DNA/RNA Synthesis Temozolomide,Gemcitabine HCl,Resveratrol,Fludarabine,Gemcitabine,Cisplatin,Fluorouracil,
Topoisomerase Doxorubicin hydrochloride, Etoposide
HDAC RGFP 966,Entinostat,Vorinostat,Mocetinostat,Panobinostat
PARP Veliparib, Olaparib, Talazoparib, Rucaparib Phosphate
Sirtuin SRT1720 hydrochloride, Resveratrol, Selisistat
Endocrinology/Hormones Androgen Receptor Enzalutamide
Estrogen/progestogen Receptor Fulvestrant
Glucocorticoid Receptor Dexamethasone
GPCR/G Protein Adrenergic Receptor Isoprenaline hydrochloride
Hedgehog/Smoothened Vismodegib, Cyclopamine
S1P Receptor Fingolimod hydrochloride
Immunology/Inflammation COX Resveratrol
IL Receptor Dexamethasone
TLR Chloroquine diphosphate
JAK/STAT signaling STAT Stattic, S3I201, Fludarabine
EGFR Erlotinib hydrochloride, Vandetanib, Lapatinib, Gefitinib, Erlotinib, Saracatinib, Osimertinib mesylate, Lapatinib Ditosylate, Neratinib, Afatinib
HER Neratinib,Afatinib
JAK Ruxolitinib,Tofacitinib Citrate,Fedratinib
MAPK ERK Selumetinib, SCH772984
JNK Pyrazolanthrone
MAPK Vemurafenib
MEK SCH772984,U0126-EtOH,Selumetinib,PD 98059,CI1040,Trametinib,PD0325901
MLK PRT062607 hydrochloride
p38 MAPK SB202190, SB203580, Doramapimod
Raf Vemurafenib,Regorafenib,Sorafenib tosylate,PLX4720,Sorafenib,Dabrafenib
S6 Kinase H 89 2HCl, BI-D1870
Membrane transporter/Ion channel ABC Vismodegib
CFTR Lumacaftor, Ivacaftor
Metabolism Casein Kinase Silmitasertib
Lipoxygenase Resveratrol
NADPH Resveratrol
PDE IBMX, Isoprenaline hydrochloride
HSP Tanespimycin, Luminespib
Amino Acids and Derivatives Pepstatin
Neuroscience Gamma-secretase DAPT, RO4929097
Adrenergic Receptor Isoprenaline hydrochloride
AChR Forskolin
Beta Amyloid DAPT, RO4929097
COX Resveratrol
NF-Κb IκB/IKK Resveratrol
PI3K/Akt/mTOR signaling GSK-3 CHIR99021
AMPK Metformin hydrochloride
mTOR Dactolisib,Tacrolimus,Capivasertib,Everolimus,Torkinib,PI103,Temsirolimus,AZD8055,Rapamycin
PI3K PI103,Buparlisib,Isoprenaline hydrochloride,LY294002 ,3-Methyladenine,Pictilisib,Torkinib,Idelalisib,Alpelisib,Dactolisib
S6 Kinase H 89 2HCl, BI-D1870
Akt Capivasertib, MK-2206 dihydrochloride
ATM/ATR KU60019, VE821, Dactolisib
DNA-PK PI103, LY294002, NU7441
Proteases/Proteasome Proteasome MG132, Bortezomib
Cysteine Protease MG132
Serine Protease LDK378
Caspase Z-VAD(OMe)-FMK
Gamma-secretase DAPT, RO4929097
Stem Cells TGF-beta/Smad LY2109761, SB525334, Galunisertib
ROCK Thiazovivin, Y-27632 dihydrochloride
Wnt/beta-catenin XAV939
Hedgehog/Smoothened Vismodegib, Cyclopamine
STAT Stattic, S3I201, Fludarabine
Casein Kinase Silmitasertib
GSK-3 CHIR99021
Gamma-secretase DAPT, RO4929097
JAK Ruxolitinib,Tofacitinib Citrate,Fedratinib
Tyrosine Kinase/Adaptors c-Kit Dasatinib,Saracatinib,Cabozantinib,Ponatinib,Sorafenib tosylate,Sunitinib Malate,Imatinib ,Regorafenib,Imatinib Mesylate,Sorafenib,Axitinib
c-Met/HGFR Cabozantinib,Crizotinib,Foretinib
IGF-1R LDK378
Src Saracatinib,Ponatinib,Dasatinib,Bosutinib,PRT062607 hydrochloride,Nintedanib,Ibrutinib
TAM Receptor Bemcentinib, Cabozantinib
Tie-2 Foretinib
Trk receptor Pyrazolanthrone
ALK LDK378, LDN193189, Crizotinib, SB525334, SB 431542
FGFR AZD4547, Ponatinib, Infigratinib, Nintedanib
FLT Sunitinib Malate, Crenolanib, Sorafenib, Sorafenib tosylate, Nintedanib, Quizartinib, Cabozantinib, Fedratinib
VEGFR AZD4547, Nintedanib, Vandetanib, Regorafenib, Foretinib, Cabozantinib, Sorafenib, Axitinib, Sunitinib Malate, Sorafenib tosylate, Ponatinib
c-RET Regorafenib, Cabozantinib, Fedratinib
EGFR Erlotinib hydrochloride, Vandetanib, Lapatinib, Gefitinib, Erlotinib, Saracatinib, Osimertinib mesylate, Lapatinib Ditosylate, Neratinib, Afatinib
HER Neratinib,Afatinib
BTK Ibrutinib, Saracatinib
PKA Capivasertib, H 89 2HCl
Tyrosine Kinases Ruxolitinib,Gefitinib,Ibrutinib,Vemurafenib
ACK Vemurafenib
Bcr-Abl Bosutinib,Ponatinib, Imatinib, Nilotinib, Imatinib Mesylate, Dasatinib
PDGFR Nintedanib,Imatinib,Crenolanib,Imatinib Mesylate,Ponatinib,Sorafenib,tosylate,Axitinib,Sunitinib Malate,Sorafenib,
Syk R406, PRT062607 hydrochloride
Ubiquitination Syk R406, PRT062607 hydrochloride
Proteasome MG132, Bortezomib